MovDisordV3, Ncbi, Merge, bibRecord, 002281

Abnormal antisaccades and smooth pursuit eye movements in patients with Wilson's disease.

Identifieur interne : 002281 ( Ncbi/Merge ); précédent : 002280; suivant : 002282

Abnormal antisaccades and smooth pursuit eye movements in patients with Wilson's disease.

Auteurs : Marcin Le Niak [Pologne] ; Anna Członkowska ; Joanna Seni W

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:18759342

English descriptors

KwdEn :
- Adult, Analysis of Variance, Electrooculography, Female, Hepatolenticular Degeneration (complications), Humans, Male, Middle Aged, Ocular Motility Disorders (etiology), Pursuit, Smooth (physiology), Reaction Time (physiology), Retrospective Studies, Saccades (physiology), Young Adult.
MESH :
- complications : Hepatolenticular Degeneration.
- etiology : Ocular Motility Disorders.
- physiology : Pursuit, Smooth, Reaction Time, Saccades.
- Adult, Analysis of Variance, Electrooculography, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult.

Abstract

Neurological symptoms in Wilson's disease (WD) may include oculomotor abnormalities. However, to date, eye movements in WD patients were rarely investigated and the data concerning this issue are sparse. The purpose of this study was to evaluate reflexive and voluntary eye movements in WD patients. We examined horizontal saccadic and smooth pursuit eye movements using infra-red oculography in 50 WD patients, including 29 neurologically symptomatic (WDn) and 21 asymptomatic ones (WDa), and in 29 healthy controls. We found statistically significant increase in mean antisaccadic latency (378 ms) and in mean antisaccadic error rate (22.5) in the WDn group, when compared with WDa group (317 ms and 9.1, respectively) and controls (318 ms and 9.7, respectively). In contrast, there were no statistically significant differences in mean latency of prosaccades and in size of the gap effect. Patients with neurological manifestations had also abnormal smooth pursuit-increased number of saccadic intrusions (mean: 8.6) and decreased gain (mean: 0.69) comparing with WDa patients (4.1 and 0.83, respectively) and controls (2.2 and 0.91, respectively). The data suggest that WD is associated both with impairment of voluntary control of saccades and with disturbed smooth pursuit eye movements while reflexive saccades seem to be preserved.

DOI: 10.1002/mds.22276
PubMed: 18759342

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002082
to stream PubMed, to step Curation: 002082
to stream PubMed, to step Checkpoint: 002458

Links to Exploration step

pubmed:18759342

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal antisaccades and smooth pursuit eye movements in patients with Wilson's disease.</title>
<author><name sortKey="Le Niak, Marcin" sort="Le Niak, Marcin" uniqKey="Le Niak M" first="Marcin" last="Le Niak">Marcin Le Niak</name>
<affiliation wicri:level="1"><nlm:affiliation>2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland. lesniak@ipin.edu.pl</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Czlonkowska, Anna" sort="Czlonkowska, Anna" uniqKey="Czlonkowska A" first="Anna" last="Członkowska">Anna Członkowska</name>
</author>
<author><name sortKey="Seni W, Joanna" sort="Seni W, Joanna" uniqKey="Seni W J" first="Joanna" last="Seni W">Joanna Seni W</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="doi">10.1002/mds.22276</idno>
<idno type="RBID">pubmed:18759342</idno>
<idno type="pmid">18759342</idno>
<idno type="wicri:Area/PubMed/Corpus">002082</idno>
<idno type="wicri:Area/PubMed/Curation">002082</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002458</idno>
<idno type="wicri:Area/Ncbi/Merge">002281</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Abnormal antisaccades and smooth pursuit eye movements in patients with Wilson's disease.</title>
<author><name sortKey="Le Niak, Marcin" sort="Le Niak, Marcin" uniqKey="Le Niak M" first="Marcin" last="Le Niak">Marcin Le Niak</name>
<affiliation wicri:level="1"><nlm:affiliation>2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland. lesniak@ipin.edu.pl</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Czlonkowska, Anna" sort="Czlonkowska, Anna" uniqKey="Czlonkowska A" first="Anna" last="Członkowska">Anna Członkowska</name>
</author>
<author><name sortKey="Seni W, Joanna" sort="Seni W, Joanna" uniqKey="Seni W J" first="Joanna" last="Seni W">Joanna Seni W</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Electrooculography</term>
<term>Female</term>
<term>Hepatolenticular Degeneration (complications)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Ocular Motility Disorders (etiology)</term>
<term>Pursuit, Smooth (physiology)</term>
<term>Reaction Time (physiology)</term>
<term>Retrospective Studies</term>
<term>Saccades (physiology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hepatolenticular Degeneration</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Ocular Motility Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Pursuit, Smooth</term>
<term>Reaction Time</term>
<term>Saccades</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Electrooculography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Neurological symptoms in Wilson's disease (WD) may include oculomotor abnormalities. However, to date, eye movements in WD patients were rarely investigated and the data concerning this issue are sparse. The purpose of this study was to evaluate reflexive and voluntary eye movements in WD patients. We examined horizontal saccadic and smooth pursuit eye movements using infra-red oculography in 50 WD patients, including 29 neurologically symptomatic (WDn) and 21 asymptomatic ones (WDa), and in 29 healthy controls. We found statistically significant increase in mean antisaccadic latency (378 ms) and in mean antisaccadic error rate (22.5) in the WDn group, when compared with WDa group (317 ms and 9.1, respectively) and controls (318 ms and 9.7, respectively). In contrast, there were no statistically significant differences in mean latency of prosaccades and in size of the gap effect. Patients with neurological manifestations had also abnormal smooth pursuit-increased number of saccadic intrusions (mean: 8.6) and decreased gain (mean: 0.69) comparing with WDa patients (4.1 and 0.83, respectively) and controls (2.2 and 0.91, respectively). The data suggest that WD is associated both with impairment of voluntary control of saccades and with disturbed smooth pursuit eye movements while reflexive saccades seem to be preserved.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18759342</PMID>
<DateCreated><Year>2008</Year>
<Month>11</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2009</Year>
<Month>04</Month>
<Day>08</Day>
</DateCompleted>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>23</Volume>
<Issue>14</Issue>
<PubDate><Year>2008</Year>
<Month>Oct</Month>
<Day>30</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Abnormal antisaccades and smooth pursuit eye movements in patients with Wilson's disease.</ArticleTitle>
<Pagination><MedlinePgn>2067-73</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22276</ELocationID>
<Abstract><AbstractText>Neurological symptoms in Wilson's disease (WD) may include oculomotor abnormalities. However, to date, eye movements in WD patients were rarely investigated and the data concerning this issue are sparse. The purpose of this study was to evaluate reflexive and voluntary eye movements in WD patients. We examined horizontal saccadic and smooth pursuit eye movements using infra-red oculography in 50 WD patients, including 29 neurologically symptomatic (WDn) and 21 asymptomatic ones (WDa), and in 29 healthy controls. We found statistically significant increase in mean antisaccadic latency (378 ms) and in mean antisaccadic error rate (22.5) in the WDn group, when compared with WDa group (317 ms and 9.1, respectively) and controls (318 ms and 9.7, respectively). In contrast, there were no statistically significant differences in mean latency of prosaccades and in size of the gap effect. Patients with neurological manifestations had also abnormal smooth pursuit-increased number of saccadic intrusions (mean: 8.6) and decreased gain (mean: 0.69) comparing with WDa patients (4.1 and 0.83, respectively) and controls (2.2 and 0.91, respectively). The data suggest that WD is associated both with impairment of voluntary control of saccades and with disturbed smooth pursuit eye movements while reflexive saccades seem to be preserved.</AbstractText>
<CopyrightInformation>(c) 2008 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Leśniak</LastName>
<ForeName>Marcin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland. lesniak@ipin.edu.pl</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Członkowska</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Seniów</LastName>
<ForeName>Joanna</ForeName>
<Initials>J</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D004585">Electrooculography</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006527">Hepatolenticular Degeneration</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D015835">Ocular Motility Disorders</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011698">Pursuit, Smooth</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012189">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012438">Saccades</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D055815">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year>
<Month>9</Month>
<Day>2</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2009</Year>
<Month>4</Month>
<Day>9</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2008</Year>
<Month>9</Month>
<Day>2</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.22276</ArticleId>
<ArticleId IdType="pubmed">18759342</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Pologne</li>
</country>
</list>
<tree><noCountry><name sortKey="Czlonkowska, Anna" sort="Czlonkowska, Anna" uniqKey="Czlonkowska A" first="Anna" last="Członkowska">Anna Członkowska</name>
<name sortKey="Seni W, Joanna" sort="Seni W, Joanna" uniqKey="Seni W J" first="Joanna" last="Seni W">Joanna Seni W</name>
</noCountry>
<country name="Pologne"><noRegion><name sortKey="Le Niak, Marcin" sort="Le Niak, Marcin" uniqKey="Le Niak M" first="Marcin" last="Le Niak">Marcin Le Niak</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002281 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002281 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:18759342
   |texte=   Abnormal antisaccades and smooth pursuit eye movements in patients with Wilson's disease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:18759342" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Abnormal antisaccades and smooth pursuit eye movements in patients with Wilson's disease.

Abnormal antisaccades and smooth pursuit eye movements in patients with Wilson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki